Mitochondrial DNA (mtDNA) characteristics and uses Assignment

Mitochondrial DNA (mtDNA) characteristics and uses - Assignment Example DNA sequence determination of the mDNA has been from many organisms including the extinct ones, and the comparison of the sequences outlines the mainstay of phylogenetics. The researchers have therefore been able to elucidate various evolutionary relationships within species. Additionally, the analysis of the relatedness of the populations among organisms has been ascertained and has become vital in the field of anthropology. The human mitochondrion DNA as an example, is commonly present per every cell except in sex cells as elucidated by Brown, George & Wilson, 1979, and is closely related to that of metazoans. The circular double-strand molecule of mDNA has about 15000 to 17000 base pairs and the nucleotide content differentiates the two strands. In animals, the transcribed strand produces molecules of polycistronic RNA. In replication process, the mDNA is replicated by the gamma complex of the enzyme DNA polymerase that is composed of 140 kDa of the catalytic section of the enzyme encoded by the gene POLG and two accessory subunits of 55 kDa encoded by POLG2 gene. During the process of embryogenesis, the mDNA replication is down because it is regulated from the oocyte that is fertilized through the embryo that is pre-implanted. At the stage of blastocyst, Anderson et al, 1981, further exemplifies that onset of the replication of the mDNA is specific to the trophectoderm cells. In contrast, the replication of mDNA is restricted by the inner cell mass cell until they receive signals making them differentiate to specific cell types. In the susceptibility concept, the mDNA does not necessarily accumulate many oxidative base damages than the nuclear DNA. As a result, some other types of the oxidative DNA damage are more efficiently repaired in the mitochondria than in the nucleus. The presence of proteins in the organelle further offers protection just as in the nuclear chromatin. The integrity of

Mental Health Article Analysis Essay Example | Topics and Well Written Essays - 250 words

Mental Health Article Analysis - Essay Example ly childhood has direct bearing on development factors later in the child’s life; as a result, more research is needed to investigate the interrelationship between these variables. The study found that boys indicated more statistically significant levels of later life external mal-adaptations than girls (d = 0.35 vs d = 0.03). The reasons for this occurrence may be because of biological issues related to gender, or that girls tend towards internalization of problems instead of externalization. Other arguments were that, â€Å"the reasons were not seeing differences is that were looking in the wrong place, and that girls have other problems..such as depression and anxiety.† While the researchers also acknowledge that the studies may not adequately account for genetic factors, they contend that there is a clear environmental correlation between insecure maternal attachment and later day externalization of maladaptive behavior. The parent’s mental health is also another variable that must be investigated as it may possibly contribute to the external behaviors. It seems that future research must investigate the underlining causes of insecure parental attachment. The research seems to predominantly place the agency on the child when it seems that the emphasis should be on everything except this variable. It’s also possible that these external behaviors are not direct an aspect of insecure attachment, but merely

The implications for UK service sector firms Essay Example for Free

The implications for UK service sector firms Essay Discuss the implications for UK service sector firms that have off shed IT or administrative functions to low cost economies, such as India. The relocation of certain industries or functions from the UK to other low-cost economies abroad has raised a number of issues over the years. From a management perspective, it is seen as a great way of reducing overheads. However, customers have identified this as a drawback in most industries today. Firstly, transferring parts of a business to a low cost economy decreases overall expenses as mentioned earlier. This could be that, the value of the pound is much stronger than that of the currency in these low cost economies so businesses have to pay much lesser total overheads. As these firms receive their revenue in pounds sterling, they would rather pay out their expenses such as electricity in Indian rupee which is about 0.01% of a pound. This is an ideological tool in exploiting different economies efficiently. It helps businesses to keep their costs very low but rather increase their profit margins. This may not always be the case though, since economic factors are very much unpredictable. Such firms are likely to have a huge loss should there be any increase in the value of the Indian currency. This could create potential instability in the business thus causing them to relocate into the UK service sector. Also, firms relocating in low cost economies are able to benefit from cheap labour costs. The increase in young, well educated workers in such economies have caused these industries to enter such markets since they are rather skilled labour that have the right skills and expertise but rather tend to demand less wages. According to statistics from the work foundation in 2004, software engineers in India received about à ¯Ã‚ ¿Ã‚ ½5000 to à ¯Ã‚ ¿Ã‚ ½15000 per annum which is a staggering 15-17% of what employees with the same position in the UK receive. This explains the use of highly skilled workforce which potentially increases productivity rate however keeping expenses such as wages at a reduced rate. Furthermore, service sectors which may have offshore are likely to gain from greater economies of scale because of the increase in the demand for the firms services. This may lead to a reduction in unit costs such as computer systems. Lower average costs should help such firms to be able to expand into different markets and to be rather competitive. However, the extent to which these firms can increase demand for their services depends whether it can meet its business objectives and attract customers since it has different departments of the business in different parts of the world. Without driving in enough customers through quality business management, the firm will certainly fall short of demand thus diseconomies of scale. Moreover, service sector firms might transfer parts of its business to places such as India to be able to benefit from cheaper land. Since in the UK, there are many restrictions to the acquisition of land, different taxes and legal permits to be able to acquire a location, it is a much wiser idea to locate in places where there are much fewer red tapes or barriers which could reduce costs. The difficulty however, could be the maintenance of quality customer services since these functions are nowhere near close to the department responsible for maintaining good customer relationships. Having mentioned all these positive implications, there may be some negatives attached to transferring a part of a business to another location. Critically, there may be some difficult ethical issues involved with this process. It may not be of good benefit to the economy if businesses were to shut down and create employment in another part of the world since employment is one of the main boosts to the economy. An increase in unemployment creates a decrease in consumer confidence which effectively means that customers would not purchase any items therefore; the government would therefore not receive huge amounts of tax. This does have a huge impact on the position of the economy and position of individuals. Another ethical issue could be; is it right to pay much lower wages abroad than in the UK? Certainly, the answer should be No. Another potential problem of off shoring is the language and cultural differences between the UK and places such as India. Communication is one of the key tools for any successful firm. Lack of understanding between colleagues might hinder the success of the firm since information will not be passed on correctly. The TalkTalk group was the most complained about provider of landline and broadband services between October 2010 and February 2011. This was majorly due to the fact that most of its customer service assistants were based outside the country which made communications between the two parties i.e. customers and customer assistants difficult. Practically all UK firms based in India have had to train their staff there, to increase their fluency in English. Certainly, this comes along with certain costs which again increase their total overheads. There might also be differences in working practices between countries, including the working hours, which can have great impact on the performance of the business. Offshoring also has an impact on the public image or reputation of a firm. A number of UK service sector companies have attracted the media over allegations of worker exploitation in low cost economies on order to reduce costs. Such media representations might reduce demand for a firms services or might also make workers feel unsafe at the workplace. These could directly have links with the mobility of demand for the firms services. Also, it is seen as a way to avoid competition in the market which then again, ruins the public image of the firm. Overall then, offshoring is a great business technique which exploits different markets but at the same time reduces costs effectively. However, it brings about some ethical issues such as the impact on the economy and also could be seen to be very costly in terms of training staff in other parts of the world because of language barrier. Also, does not take the interest of its customers who are a great asset to every firm, into concern. It is therefore with no doubt that most businesses are moving back to the UK since it has been discovered that the negatives of offshoring do outweigh the positives.

Changes in Rita and Frank in Education Rita Essay -- Education Rita Li

Changes in Rita and Frank in Education Rita Discuss the ways in which Russell portrays the changes and developments in the characters of Rita and Frank in Act 1 Scene 1 and Act 2 scene 1 Drama (post 1914) Discuss the ways in which Russell portrays the changes and developments in the characters of Rita and Frank in Act 1 Scene 1 and Act 2 scene 1 of ‘Educating Rita’. ‘Educating Rita’ is a play written by the British author Willy Russell. It is set in Liverpool around the 1980’s. It explores the themes of education, poverty and working class life. The play is based on Rita’s enthusiasm and determination to be educated. Rita undergoes her course at the Open University. Here she meets her tutor Frank and it is here their plutonic relationship blossoms. This is what occurs in Act 1 scene 1. In Act 2 scene 1 the relationship contrasts from that of the previous act. Although they have this friendly love, Frank becomes jealous of Rita. This is because when Rita returns from her summer school she is a new woman. She is more educated, has acquired new clothes and her accent has changed. The play is structured in two acts. It has eight scenes in the first act and seven scenes in the second act. The first scene of act one is set in Frank’s office at the Open University. There is a large bay window at the left of his room and a small desk positioned in front of it. In the centre of the room there is a larger desk covered with books and papers. The walls are also lined with books. On one wall hangs a nude religious scene. The way in which the scene is set gives the reader a first impression that Frank is a disorganised person. Yet when we see all the books we assume that he is an intelligent person too. ... ... what she thinks when she tells him she is disappointed that he is still drinking after the summer. This is different to Act 1 scene 1 when Rita would only agree with what Frank would say. Rita entered the play as a clumsy and uneducated woman and has come through to Act 2 scene 1 as an educated and independent woman. Willy Russell has portrayed the changes in Rita by giving her a new outlook on life and a new education. Frank was very intrigued when he first met Rita in Act one Scene one, but now he is jealous of the changes that have occurred during the summer break and brought her into his office in Act 2 Scene 1 as a fresh, self confident woman. Willy Russell has portrayed the changes in Frank in a very clever way. Although he never directly refers to the changes all you have to do is look back and compare the two acts and the changes are obvious.

Continuum of Strategies

Continuum of Strategies Sylvia Brooks, Kenya Conyers, Jennifer Williams SEI/500 Structured English Immersion October 22, 2012 Dr. Gretchen Meyer Continuum of Strategies Introduction: Mrs. Brooks is a first grade teacher in Harvard Elementary School and this year she has twenty five students in her classroom. Of the twenty five students in her classroom, five are English Language Learners. These five students are all Spanish speaking but two are from Puerto Rico and three are of Mexican descent. Mrs. Books has found that two of the five children speak English also.Today’s lesson in Social Studies is titled Community Workers. In this lesson we will begin with the teacher centered strategy. The lesson will also include the teacher assisted, peer assisted, and student centered strategies. Teacher-Centered: Mrs. Brooks began her lesson by using the teacher-centered strategy of lecture. She informed the children that they would begin a unit entitled Community Workers, and doing a pi cture walk from the book. Mrs. Brooks has everyone to put there finger on the title and repeat the title together â€Å"Community Workers†.Next she asks the students for suggestions as to who do they think is a community worker? Mrs. Brooks talks about each suggestion then tells the children to look at the pictures on the next page. The children are given thirty seconds to tell their partner the name of the person in the picture. Then the teacher tells them the correct way to say the name of person in English and proceeds to the next picture (Echevarria, Vogt, & Short, 2008). The same process continues until the end of the story and the children can verbally identify the names of the community workers.Teacher-Assisted: After the story is completed, Mrs. Brooks began using a teacher assisted strategy. Mrs. Brooks brought out several boxes and placed them on the table. The children stayed with his or her partner. Each group was given a box with the description of a community wo rker inside. Inside each box were several items that were in English along with a picture attached. Each group was able to look into their box and decide what they were going to discuss with the rest of the class. The groups were given about three minutes to have their description ready to present to the class.Once each group had finished presenting their community worker, Mrs. Brooks passed out a worksheet to be completed. Peer Assisted: Before completing the worksheets, the students swapped partners so that one student from each group could discuss their community worker with another student. The students were instructed to write down key elements about each community worker. The students were given 3 minutes and after 3 minutes were up the pairs swapped again. This continued until all students had paired up to cover all five community workers covered.After this students were given directions to complete the worksheet. Student-Centered: Students were directed to complete the works heet by using the notes taken during the â€Å"pair swap†. Students were also able to refer back to the elements used in their presentations in order to complete worksheet. After completing worksheet, students were allowed time to share and discuss answers. Conclusion: After completing each activity on community workers, the teacher began reviewing the lesson that was taught. She began asking questions about community workers.She asked the students to name several community workers, what they do, and if they wear a uniform. The workers that were left out she held up pictures of the workers and allowed the students to answer questions about them. Mrs. Brooks saw that the students retain the information that was taught and enjoyed learning about community workers. References Echevarria, J. , Vogt, M. , & Short, D. J. (2008). Making Content Comprehensible for English Learners. The SIOP ® Model, Third Edition  (3rd ed. ). Boston, MA: Allyn & Bacon, Inc. A Pearson Education Co mpany.

Does a Revolution Always Have to Include Terror Essay

The radical leader of the Committee of Public Safety, Robespierre had fanatic and opinionated ideas and beliefs that made him a passionate leader. He believes that to safely go through the stormy revolution, the people’s behavior should be regulated by stormy circumstances, and their plans should be based on the combination of the spirit of revolutionary government and democracy. Virtue, the â€Å"fundamental principle of the democratic government,† was a strong factor of his viewpoint. He thinks that if there is no virtue in the government, then the people’s virtue can be a source, but when the people are corrupted too, there is no chance of winning liberty. These ideas did no harm; they were beneficial and very true. However, he also had radical ideas that were appalling and that weren’t necessarily correct. In his opinion, the people should be lead by reason and the people’s enemies by terror. Robespierre also mentions that a popular government in revolution evolves from virtue and terror. This is his outlook on virtue and terror: â€Å"virtue, without terror is fatal; terror, without which virtue is powerless.† He says, â€Å"the characteristic of popular government is confidence in the people and severity towards itself.† In other words, the popular government has to have confidence in the people and be strict and severe with itself. According to him, terror is the principle of despotic government and he thinks that because of this, the despot may govern by terror his brutalized subjects and subdue by terror the enemies of liberty. Even though these are only his opinions, his perspectives on the use of terror and ruthlessness led him to cause the Reign of Terror and ultimately led him to his execution on July 28, 1794. A revolution doesn’t necessarily have to include terror and the popular government does not have to be ruthless to its people, because then the revolutionaries may lose their supporters (or they may even revolt) and the radicals might have to face more enemies. This was true, because Robespierre’s former followers had him arrested and executed, and the day after the execution, everyone felt relieved. The famous radical leader’s attributes and beliefs led the country into terror and himself to his end.

Shakespeare Family

Shakespeare Family Who was William Shakespeare’s immediate family? Did he have children? Are there direct descendants around today? William led two very different lives. There was his home, family life in Stratford-upon-Avon; and there was his professional life in London. Other than one account from a town clerk in 1616 that Shakespeare was in London with his son-in-law, John Hall, there is no evidence that his family had much to do with London. All of his property was in Stratford, including a large family home called New Place. When purchased in 1597, it was the biggest house in the town! Shakespeares Parents: Father: John ShakespeareMother: Mary Arden There is no exact record of when John and Mary married, but it is estimated to be in about 1557. The family business evolved over time, but it is widely recognised that John was a glove maker and leather maker.   John was very active in Stratford-upon-Avon’s civic duties and in 1567 he became mayor of the town (or High Bailiff, as he would have been titled then). Whilst there are no records, it is presumed that John’s high civic standing would have enabled the young William to study at the local grammar school. Shakespeares Siblings: Brother: Gilbert Shakespeare (born in 1566)Sister: Joan Shakespeare (born in 1569)Sister:  Anne Shakespeare (born in 1571)Brother:  Richard Shakespeare (born in 1574)Brother:  Edmund Shakespeare (born in 1580) Infant mortality was common in Elizabethan England, and John and Mary lost two children before William was born. The siblings above lived until they were adults, with the exception of Anne who died at the age of eight. Shakespeares Wife: Wife: Anne Hathaway When he was just 18 years old, William married 27-year-old Anne Hathaway in a shotgun wedding. Anne was the daughter of a farming family in the nearby village of Shottery. She fell pregnant with their first child outside of wedlock and the couple had to obtain special permission from the Bishop to marry. There is no surviving wedding certificate. Shakespeares Children: Daughter: Susanna Shakespeare (born in 1583)Daughter:  Judith Shakespeare – Twin (born in 1585)Son: Hamnet Shakespeare – Twin (born in 1585) The child conceived out of wedlock to William Shakespeare and Anne Hathaway was daughter named Susanna. A few years later, they had twins. However, in the summer of 1596, Hamnet died, aged 11. It is thought that William was grief stricken and his experience can be read in his characterisation of Hamlet, written not long after. Susanna married John Hall in 1607; Judith married Thomas Quiney in 1616.Shakespeares Grandchildren: Elizabeth Hall (born in 1608)Shakespeare Quiney (born in 1616)Richard Quiney (born in 1618)Thomas Quiney (born in 1620) William had only one grandchild from his eldest daughter, Susanna. Elizabeth married Thomas Nash in 1626, and later remarried to John Bernard in 1649. From William’s youngest daughter, Judith, there were three grandsons. The eldest was named Shakespeare because the family name had been lost when Judith married, but he died in infancy. Shakespeares Grandparents Grandfather: Richard ShakespeareGrandfather: Robert Arden Above William’s parents in the family tree, information becomes a little sparse. We can’t be sure of the names of William’s grandmothers because the â€Å"men of the house† would have taken control of legal affairs, and so only their names will have appeared on historical documents. We know that the Arden’s were wealthy fathers and the Shakespeare family held civic responsibilities in the town. It is likely that this combined power was what enabled them to obtain special permission from the Bishop for their children to marry to stop the baby being born out of wedlock; this would have brought shame on their family and their reputation at the time. Shakespeares Living Descendants: Wouldn’t it be great to discover that you are a descendant of the Bard? Well, technically, it is possible. The direct bloodline ends with William’s grandchildren who either did not marry, or did not have children to continue the line. You have to look further up the family tree to William’s sister, Joan. Joan married William Hart and had four children. This line continued and there are many of Joan’s descendants alive today. Could you be related to William Shakespeare?